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Mike suspects the local water supply has been contaminated by a mining company. Mike run mercury tests on his property, she forces a reluctant Sully to guide her to the high mountain stream which may be the source of the problem. Mike about the baby, who tries to find a home for him, but potential parents prove unwilling or unsuitable. While she is finishing the grave, a brown bear turns up and her horse is frightened off. Matthew buys all of Ingrid's dance tickets, but Ingrid cries when it appears no one wants to dance with her. Mike catches Matthew and Ingrid kissing in the barn, Ingrid has an asthma attack.The trek is difficult for her but she ultimately earns Sully's respect and gratitude after saving his life despite a broken wrist. When she travels to a remote cabin to check on the health of Luke Silver as a favor to the Reverend, she finds him badly mangled from a bear attack. She overjoyed to learn Matthew wanted her all to himself. Mike there is an emergency but the townspeople surprise her with a birthday party. Michaela worries that Matthew might do something he'll regret and they are at odds over his future. Matthew storms off, frustrated by her over-protectiveness and his desire for independence. Mike tries to tell her Sully doesn't love her romantically, but only as a friend.Eventually, Miss Olive drops the charges and tells Matthew and Jon they are going to work off the cow.Loren discovers he holds the deed for the property Sully built the homestead on that Dr. Sully assumed he inherited the property from his deceased wife, Abagail, Loren's daughter. Mike discovers that the railroad has hired hunters to clear buffalo herds and Indians out of a proposed railroad path.When she arrives in Colorado Springs in 1867, she is met with derision and hostility by most of the townspeople except Charlotte Cooper (Diane Ladd) and “mountain man” Byron Sully (Joe Lando).Charlotte is matron of the local boarding house and struggling to support her three children, Matthew (Chad Allen), Colleen (Erika Flores), and Brian (Shawn Toovey), after her husband skipped town with their savings. She is hit especially hard after failing to get a shipment of medicine in time to treat Maude Bray, who suffers a fatal heart attack. The town grudgingly begins to accept her as a woman doctor. Quinn, Medicine Woman is an American Western drama series created by Beth Sullivan and starring Jane Seymour who plays Dr.Michaela "Mike" Quinn, a physician who leaves Boston in search of adventure in the Old American West and who settles in Colorado Springs, Colorado.
Several townspeople come down with mercury poisoning, and Dr. Matthew, who has a crush on an immigrant girl named Ingrid, sees this as his chance to express his feelings toward her when tickets are offered to dance with the girls.
After consulting Jake for treatment of a hernia, Loren asks Dr. She tells him he needs an operation to repair it or risk fatal complications. Mike says it is time for him to finally put Abagail to rest. Loren later admits to Sully he came to realize that his plans for Abagail were not her plans but was too proud to ever tell her. She tries to stop Sully from fighting Rankin, the leader of the buffalo hunters, and goes to the Cheyenne.
He refuses to listen and gets angry, telling both Dr. Loren gets drunk, attempts to fight with Sully, and falls unconscious. Mike performs surgery on Loren with help from Sully and Colleen, whose image in the eyes of her friends is subsequently enhanced. He gives Sully the deed for the homestead property. Mike and the Cooper children who are packing up to leave. Mike asks him what he would like to do with a chest that belonged to Abagail which he left there. Mike asks him to stay for dinner saying they have a lot to celebrate. They both escape after Sully traps the bear in the barn. Later, Chief Black Kettle refuses to take the child because he can't feed his own children. Black Kettle says they won't interfere as it is Sully's fight, and Cloud Dancing tells Dr. When Sully confronts the buffalo hunters, a mystical white buffalo (Running Ghost) appears to avenge the animals' deaths. As Rankin goes to shoot Sully, Running Ghost appears and kills Rankin.
Hank takes bets from the townspeople on Loren's survival, and Horace provides a play-by-play while peeking through the clinic window. He stares at their wedding picture which was in the chest and finally tells Dr. Ethan Cooper (Ben Murphy) arrives in Colorado Springs “a reformed man” ready to reconnect with the children he abandoned who are now in Dr. Brian, Colleen, and eventually Matthew are drawn into his orbit, and Michaela feels helpless and confused. After ambushing Black Kettle's camp, General Custer enters the town with wounded soldiers and Indian prisoners, including Cloud Dancing, whom Custer threatens to kill if Dr. Custer then threatens to execute Cloud Dancing if he doesn't give him the information he wants in two days.
The townspeople plan a Founders Day Auction to raise money for the new school. Mike joins the ladies’ quilting circle where she clashes with Miss Olive over small pox vaccinations, Dr. Eventually, Ethan reveals himself to be a con man whose real intention is to steal the town's auction proceeds, a scheme foiled by a suspicious Sully. Cloud Dancing is later badly beaten and suffers a dislocated arm which Dr. She goes to Reverend Johnson, but he refuses to speak to Custer.