Fluoridating remineralizing of enamel
5,624,906 describes an oral hygiene composition comprising a heteroatom containing alkyl aldonamide compound (e.g., alkoxymethyl gluconamide). These kits are based on the finding that maintaining the soluble calcium, soluble orthophosphate, and the soluble peroxide components in one or more separate environments prior to use is surprisingly beneficial for optimizing the stability and/or activity of these components. Kits of the present invention employ a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide.The compositions advantageously whiten teeth while simultaneously remineralizing them to prevent and/or repair weaknesses including dental caries, exposed dentin tubules, and voids resulting from stain removal. The stabilized peroxide composition comprises a soluble peroxide and a soluble orthophosphate salt.
In particular, without being bound by theory, it has now been determined that (i) peroxide in solution may be stabilized in the presence of orthophosphate ion and/or in a composition at acidic p H, (ii) conversely, in order for peroxide to become activated for tooth whitening upon use, it may be destabilized by removing the soluble orthophosphate ion and/or increasing p H, and (iii) calcium orthophosphate solutions at high concentrations suitable for tooth remineralization may be stabilized at acidic p H and precipitated onto the tooth surface by increasing p H.In another preferred embodiment, the composition further comprises a source of fluoride ions and/or a source of carbonate ions.In yet another embodiment, the present invention is a method for whitening and remineralizing teeth. There is also a need in the art for methods that achieve simultaneous whitening and remineralization of teeth in this manner. 5,849,269; 5,820,852; and 5,776,437 describe oral compositions comprising a fluoride ion source, pyrophospate, and calcium peroxide. There is an ongoing need in the art for compositions that whiten teeth and also remineralize them by filling voids associated with tooth decay, mechanical injury, and/or organic stain removal.